© 2018 by Eri Hashino. 

MODELING INNER EAR DEVELOPMENT AND DISEASE

3D STEM CELL BIOLOGY

DEVELOPMENT

 

How do multipotent otic progenitors give rise to different cell types in the human inner ear during embryonic development?  What degree do these progenitors possess the potential to switch cell fates?  

DISEASE

 

How do certain genetic mutations cause abnormal development of inner ear structure and function?  Are there ways to delay or reverse abnormal development of the inner ear?

 

REGENERATION

 Do small molecules with the ability of promoting hair cell differentiation promote hair cell regeneration in the human inner ear?  Does inhibition of a histone demethylase promote hair cell differentiation and/or regeneration?

 

 

Walther Hall