PUBLICATIONS

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Ueda Y, Moore ST, Hashino E (2021) Directed differentiation of human pluripotent stem cells into inner ear organoids. Methods in Molecular Biology.

 

Romano DR, Hashino E, Nelson RF (2021) Deafness-in-a-dish: Modeling human deafness with inner ear organoids.

 

Tucker B, Chen YS, Shin T, Cabrera E, Hashino E, Booth K, Nelson RF (2021) Cochlear implant outcomes with patients with TMPRSS3 genetic mutations.

 

Romano DR, Solivais AJ, Nie J, Chen L, Hashino E (2021) Single-cell RNA sequencing analysis with AutoClustR reveals the cellular diversity of human inner ear organoids.  

Romano DR, Heller S, Hashino E (2020) Stem Cells and Small Molecules. In: Audition, Elsevier (in press).

Tang PC, Hashino E, Nelson RF (2020) Progress in modeling and targeting inner ear disorders with pluripotent stem cells.  Stem Cell Reports 14(6): 996-1008.

Nie J, Hashino E (2020) Generation of inner ear organoids from human pluripotent stem cells.  Methods in Cell Biology 159: 303-321.

Janesick A, Hashino E, Heller S (2020) Inner ear cells from stem cells – a path towards inner ear regeneration.  In: ME Warchol, JS Stone, AN Popper (Eds.), Hair Cell Regeneration, Springer (in press).

Tang PC, Alex AL, Nie J, Lee J, Roth AA, Booth KT, Koehler KR, Hashino E, Nelson RF (2019) Defective Tmprss3-associated hair cell degeneration in inner ear organoids.  Stem Cell Reports 13(1):147-162. 

Patel D, Shimomura A, Holley MC, Hashino E (2018) The histone demethylase LSD1 regulates inner ear progenitor differentiation through direct interactions with Pax2 and the NuRD complex. PLOS ONE 13(1):e0191689.

 

Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E (2017) Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells.  Nature Biotechnology 35(6):583-589.

 

Nie J, Hashino E (2017) Organoide technologies meet genome engineering. EMBO Reports 18(3):367-376. 

 

Nie J, Koehler KR, Hashino E (2017) Directed differentiation of mouse embryonic stem cells into inner ear sensory epithelia in 3D culture. Methods In Molecular Biology 1597: 67-83.

 

Elghouche AN, Nelson RF, Hashino E (2017)  Inner ear organoids: Recapitulating inner ear development in 3D culture.  In: T. Tsuji (Ed.), Organ Regeneration Based on Developmental Biology, Springer Nature, pp.57-72.

 

DeJonge RE, Liu XP, Deig C, Heller S, Koehler KR, Hashino E (2016) Modulation of Wnt signaling enhances inner ear organoid development in 3D culture.  PLOS ONE 11(9):e0162508.

 

Liu XP, Koehler KR, Mikosz AM, Hashino E*, Holt JR* (2016) Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.  Nature Communications 7:11508.  *; Co-Corresponding authors.

 

Longworth-Mills E, Koehler KR, Hashino E (2016) Generating inner ear organoids from mouse embryonic stem cells.  Methods In Molecular Biology 1341: 391-406.

 

Shimomura A, Patel D, Wilson SM, Koehler KR, Khanna R, Hashino E (2015) Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.  PLOS ONE 10: e0135060.

 

Koehler KR, Hashino E (2014) Converting embryonic stem cells into inner ear sensory epithelia in 3D culture.  Nature Protocols 9: 1229-1244.

 

Koehler KR, Malone AK, Hashino E (2014) Recapitulating inner ear development with pluripotent stem cells: biology and translation.  In: R. Romand and I. Varela-Nieto (Eds.), Development of the Auditory and Vestibular Systems 4th edition, Elsevier, San Diego, pp.214-247.

 

Koehler KR, Mikosz AM, Molosh AI, Patel D, Hashino E (2013) Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture.  Nature 500: 217-221.

 

Romand R, Krezel W, Fraulob V, Messaddeq N, Kessler P, Bianchetti L, Cammas L, Hashino E, Dolle P (2013) Retinoic acid deficiency impairs the vestibular function.  Journal of Neuroscience 33: 5856-5866.

 

Shimomura A, Hashino E (2013) Epigenetic regulation of neuronal differentiation from embryonic stem cells.  In: S. Wislet-Gendebien (Ed.), Trends in Cell Signaling Pathways in Neuronal Fate Decision, INTECH, Rijeka, Croatia, pp.305-325.

 

Vemula S, Shi J, Mali RS, Ma P, Hanneman PH, Koehler KR, Wei L, Hashino E, Kapur R (2012) ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.  Blood 120: 2868-2878.

 

Krishnan S, Mali RS, Koehler KR, Vemula S, Chatterjee A, Ghosh J, Ramdas B, Ma P, Hashino E, Kapur R (2012) Class IA PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes.  PLos One 7: e28979.

 

Kondo T, Matsuoka AJ, Shimomura A, Koehler KR, Chan RJ, Srour EF, Miller JM, Hashino E (2011) Wnt signaling promotes neuronal differentiation from somatic pluripotent stem cells through activation of Tlx3.  Stem Cells 29: 836-846.

 

Hashino E, Fritsch MH (2011) Embryonic stem cell-derived neurons for inner ear therapy.  In: C. Atwood (Ed.), Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine, INTECH, Rijeka, Croatia, pp.189-202.

 

Koehler KR, Tropel P, Thiele JW, Kondo T, Cummins TR, Viville S, Hashino E (2011) Extended passaging increases efficiency of neural differentiation from induced pluripotent stem cells.  BMC Neuroscience. 12:82.

 

Ma P, Vemula S, Munugalavadla V, Chen J, Sims E, Borneo J, Kondo T, Mali RS, Ramdas B, Li S, Hashino E, Takemoto C, Kapur R (2011) Balanced interactions between Lyn, p85α regulatory subunit of class IA phosphatidylinositol-3-kinase and SHIP is essential for mast cell growth and maturation.  Mol. Cell. Biol. 31: 4052-4062.

 

Yang Z, Kondo T, Voorhorst CS, Nabinger SC, Ndong L, Yin F, Chan EM, Niemeyer CM, Kratz CP, Flotho C, Hashino E, Chan RJ (2009) Increased c-Jun and reduced GATA2 promotes aberrant monocytic differentiation induced by activating PTPN11 mutants.  Mol. Cell. Biol. 29: 4376-4393.

 

Kondo T, Sheets PL, Zopf DA, Aloor HL, Cummins TR, Chan RJ, Hashino E (2008) Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells.  Proc. Natl. Acad. Sci. USA 105: 5780-5785.