© 2018 by Eri Hashino. 

PUBLICATIONS

Tang PC, Alex AL, Nie J, Lee J, Roth AA, Booth KT, Koehler KR, Hashino E, Nelson RF (2019) Defective Tmprss3-associated hair cell degeneration in inner ear organoids.  Stem Cell Reports 13(1):147-162. 

Patel D, Shimomura A, Holley MC, Hashino E (2018) The histone demethylase LSD1 regulates inner ear progenitor differentiation through direct interactions with Pax2 and the NuRD complex. PLOS ONE 13(1):e0191689.

 

Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E (2017) Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells.  Nature Biotechnology 35(6):583-589.

 

Nie J, Hashino E (2017) Organoide technologies meet genome engineering. EMBO Reports 18(3):367-376. 

 

Nie J, Koehler KR, Hashino E (2017) Directed differentiation of mouse embryonic stem cells into inner ear sensory epithelia in 3D culture. Methods In Molecular Biology 1597: 67-83.

 

Elghouche AN, Nelson RF, Hashino E (2017)  Inner ear organoids: Recapitulating inner ear development in 3D culture.  In: T. Tsuji (Ed.), Organ Regeneration Based on Developmental Biology, Springer Nature, pp.57-72.

 

DeJonge RE, Liu XP, Deig C, Heller S, Koehler KR, Hashino E (2016) Modulation of Wnt signaling enhances inner ear organoid development in 3D culture.  PLOS ONE 11(9):e0162508.

 

Liu XP, Koehler KR, Mikosz AM, Hashino E*, Holt JR* (2016) Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.  Nature Communications 7:11508.  *; Co-Corresponding authors.

 

Longworth-Mills E, Koehler KR, Hashino E (2016) Generating inner ear organoids from mouse embryonic stem cells.  Methods In Molecular Biology 1341: 391-406.

 

Shimomura A, Patel D, Wilson SM, Koehler KR, Khanna R, Hashino E (2015) Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.  PLOS ONE 10: e0135060.

 

Koehler KR, Hashino E (2014) Converting embryonic stem cells into inner ear sensory epithelia in 3D culture.  Nature Protocols 9: 1229-1244.

 

Koehler KR, Malone AK, Hashino E (2014) Recapitulating inner ear development with pluripotent stem cells: biology and translation.  In: R. Romand and I. Varela-Nieto (Eds.), Development of the Auditory and Vestibular Systems 4th edition, Elsevier, San Diego, pp.214-247.

 

Koehler KR, Mikosz AM, Molosh AI, Patel D, Hashino E (2013) Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture.  Nature 500: 217-221.

 

Romand R, Krezel W, Fraulob V, Messaddeq N, Kessler P, Bianchetti L, Cammas L, Hashino E, Dolle P (2013) Retinoic acid deficiency impairs the vestibular function.  Journal of Neuroscience 33: 5856-5866.

 

Shimomura A, Hashino E (2013) Epigenetic regulation of neuronal differentiation from embryonic stem cells.  In: S. Wislet-Gendebien (Ed.), Trends in Cell Signaling Pathways in Neuronal Fate Decision, INTECH, Rijeka, Croatia, pp.305-325.

 

Vemula S, Shi J, Mali RS, Ma P, Hanneman PH, Koehler KR, Wei L, Hashino E, Kapur R (2012) ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.  Blood 120: 2868-2878.

 

Krishnan S, Mali RS, Koehler KR, Vemula S, Chatterjee A, Ghosh J, Ramdas B, Ma P, Hashino E, Kapur R (2012) Class IA PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes.  PLos One 7: e28979.

 

Kondo T, Matsuoka AJ, Shimomura A, Koehler KR, Chan RJ, Srour EF, Miller JM, Hashino E (2011) Wnt signaling promotes neuronal differentiation from somatic pluripotent stem cells through activation of Tlx3.  Stem Cells 29: 836-846.

 

Hashino E, Fritsch MH (2011) Embryonic stem cell-derived neurons for inner ear therapy.  In: C. Atwood (Ed.), Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine, INTECH, Rijeka, Croatia, pp.189-202.

 

Koehler KR, Tropel P, Thiele JW, Kondo T, Cummins TR, Viville S, Hashino E (2011) Extended passaging increases efficiency of neural differentiation from induced pluripotent stem cells.  BMC Neuroscience. 12:82.

 

Ma P, Vemula S, Munugalavadla V, Chen J, Sims E, Borneo J, Kondo T, Mali RS, Ramdas B, Li S, Hashino E, Takemoto C, Kapur R (2011) Balanced interactions between Lyn, p85α regulatory subunit of class IA phosphatidylinositol-3-kinase and SHIP is essential for mast cell growth and maturation.  Mol. Cell. Biol. 31: 4052-4062.

 

Yang Z, Kondo T, Voorhorst CS, Nabinger SC, Ndong L, Yin F, Chan EM, Niemeyer CM, Kratz CP, Flotho C, Hashino E, Chan RJ (2009) Increased c-Jun and reduced GATA2 promotes aberrant monocytic differentiation induced by activating PTPN11 mutants.  Mol. Cell. Biol. 29: 4376-4393.

 

Kondo T, Sheets PL, Zopf DA, Aloor HL, Cummins TR, Chan RJ, Hashino E (2008) Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells.  Proc. Natl. Acad. Sci. USA 105: 5780-5785.